Cialis (Tadalafil) is a medication used for several medical purposes, including erectile dysfunction in men, pulmonary arterial hypertension, and recently approved for treatment of benign prostatic hyperplasia (BPH), which the inflammation of the prostate. However, the most frequent application of Tadalafil is erectile dysfunction (ED).
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Cialis, Viagra and Levitra
The commercial name of Tadalafil is Cialis. The drug is included in the class of drugs called phosphodiesterase type 5 inhibitors, which are simply known as PDE5 inhibitors. Sildenafil (Viagra) and Vardenafil (Levitra) also share the same category with Tadalafil, but they are slightly different in the duration of their effects. All PDE5 inhibitor drugs work by substantially increasing the blood flow in the blood vessels of the penis, which causes a solid erection. However, Tadalafil maintains its effective action for up to 36 hours, unlike sildenafil or vardenafil, which have substantially shorter effects. It is the reason why Cialis is sometimes known to be called as the “weekend pill”.
How to use Cialis
For erectile dysfunction, Cialis is not taken regularly, but only when needed (available dosage: 5mg, 10mg and 20 mg). Tadalafil also can lower the high blood pressure in the lung blood vessels, through its potent blood vessel dilation effects, which is useful for individuals suffering from pulmonary arterial hypertension.
How its works
How does Tadalafil work to help a man with ED achieve a strong erection and enhance his love life? When sexual arousal is experienced by an individual, the nerves that are distributed to the cavernous bodies of the penis release a signaling agent called nitric oxide (NO). This signaling agent stimulates an enzyme to produce an active chemical compound called cGMP, which in turn directly affects the blood vessels in the penis provoking their strong dilation and substantial blood entry in the cavernous bodies of the penis. As long as there is sufficient cGMP, the erection is maintained effectively and sexual intercourse is possible. However, the effects of cGMP as a potent blood vessel dilation agent are ended by an enzyme called PDE5, which neutralizes cGMP and terminates its action.
This mechanism can be used to enhance an erection through pharmaceutical drugs. Specifically, drugs such as Tadalafil are able to block PDE5 enzyme, which greatly prolongs the dilation effects of cGMP, and therefore, helps preserve an effective and healthy erection. The same enzyme is also found in the blood vessels of the lung, which is why Tadalafil is also effective for pulmonary arterial hypertension.
Tadalafil is an accurately clinically tested drug and it is not associated with severe side effects. Minor and temporary side effects may occur, and they may include headaches and facial rash, as a result of blood vessel dilation, digestive disturbances and nausea. These adverse effects usually disappear quickly after the dosage is adjusted or after the individual becomes adapted to the medication.