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Ciprofloxacin, commonly known as Cipro, is a broad-spectrum antibiotic patented by Bayer in 1983. Since then Cipro has continued to be very popular and widely prescribed for a variety of uses, some approved by the FDA, and just as many common but off-label applications. Cipro works well against both Gram-negative and Gram-positive bacteria, attacking the bacteria’s enzymes and DNA, and disrupting its ability to grow via cell division.
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Product Description
A great financial success for its developers, bringing in billions of dollars over three decades, Cipro drew a certain amount of positive media attention during the anthrax attacks of 2001 as the most effective counter-measure against inhalation anthrax. It is effective and relatively safe but has some significant drawbacks. As with all other antibiotics, and particularly antibiotics of its class (flouroquinolones), its mis-use, over-use and abuse in the last few years has promoted antibiotic resistance in quickly-evolving pathogens. This has undermined its own effectiveness and raised the spectre of a new generation of drug-resistant disease, and the danger of a public health disaster.
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Studies in 2002 found that a full 42% of all prescriptions for flouroquinolones went for unapproved off-label applications like bronchitis, simple sore throats, and viral infections. Cipro was chief among them. Secondly, more specific to Cipro itself, is its unpredictable interaction with other drugs, herbal supplements, natural supplements, and even food items such as milk, yogurt, and grapefruit juice. For these reasons prescribing Cipro can be tricky. It’s indicated for many infections like typhoid fever and infectious diarrhea, but is broadly not recommended for children because of potential muscle and bone damage, and not recommended as a first-line agent for a list of other infections. Because of historic over-use it’s not recommended against sexually transmitted diseases or against tuberculosis. Patients dependent on other medications, particularly older patients, are at risk of adverse interactions. Cipro should always be carefully prescribed by a knowledgeable physician.
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