Kamagra Jelly is the prescription drug trade name for Sildenafil Citrate produced in Australia where patent does not apply. Kamagra is a generic for the widely known Viagra. Kamagra Jelly is more quickly absorbed than traditional Sildenafil and provides a better sexual experience as far as achieving and maintaining erections. Kamagra Jelly can also extend sexual experience and reduce recovery time between orgasms. The common uses for Kamagra include treatment of erectile dysfunction as well as pulmonary arterial hypertension.
Off label and promising uses include the treatment of depression due to sexual dysfunction in men as well as altitude sickness related to pulmonary edema. Use of Kamagra has become the standard in treatment of erectile dysfunction for men with diabetes mellitus. Research has shown that the most common side effects of Kamagra use included headache, flushing, indigestion, nasal congestion, and impaired vision, including photophobia and blurred vision. On occasion Kamagra users have complained of seeing everything tinted blue. Some complained of blurriness and loss of peripheral vision. Other side effects include prolonged erections, severe low blood pressure, heart attack, ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. More severe interactions may occur with people who are also taking protease inhibitors for the treatment of HIV, erythromycin and cimetidine as well as alpha blockers taken in a short period of time. Taking Kamagra in conjunction with any of the following is not recommended: organic nitrites and nitrates, nitroglycerin, sodium nitroprusside, amyl nitrite (“”poppers””). Kamagra is also not recommended to be taken by those with the following conditions: decreased liver function, severe impairment in renal function, low blood pressure, recent stroke or heart attack, and hereditary degenerative retinal disorders. The way Kamagra works as explained from a pharmacokinetic and biological chemistry standpoint is that by protecting cyclic guanosine monophosphate from breaking down in the corpus cavernosum. Nitric oxide in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which leads to increased levels of cGMP, causing the intimal cushions of the helicine arteries. This smooth muscle relaxation leads to vasodilation and increased inflow of blood into the spongy tissues of the penis, this causes an erection. Kamagra is a potent and selective inhibitor of cGMP-specific phosphodiesterase. This is responsible for degradation of cGMP in the corpus cavernosum.
The molecular structure of Kamagra is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, Kamagra should not cause an erection. Kamagra is metabolized in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4, but also by CYP2C9 hepatic isoenzymes. The main product of metabolization by these enzymes is N-desmethylated sildenafil, which is metabolised further. This metabolite also has an affinity for the PDE receptors, about 40% of that of Kamagra. Thus, the metabolite is responsible for about 20% of Kamagra action. Kamagra is excreted as metabolites predominantly in the feces and to a lesser extent in the urine. If taken with a high-fat meal, the absorption of Kamagra is reduced; the time taken to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly 33%
I am self employed. General Practitioner in Melbourne, VIC. My special interest: male reproductive system.