Since 1998, Viagra has been used primarily as a drug to overcome erectile dysfunction to provide an enhanced sex life for men with problems getting or maintaining an erection. Causes of erectile dysfunction can include prostate issues (including enlarged prostate and prostate cancer treatments), obesity, heart disease, diabetes, normal aging of the body, and depression. Stress and other psychological factors can also increase instances of erectile dysfunction. Viagra, which is the brand name for the drug Sildenafil citrate, can alleviate erectile dysfunction in those cases so that men experiencing physical or psychological problems that cause difficulty having or maintaining an erection may experience a more normal sex life.
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The way Viagra works is that it inhibits an enzyme that degrades cGMP, which is a cyclic nucleotide that helps relax blood vessels to allow for vasodilation and increased blood flow. Vasodilation is the mechanism by which blood vessels widen to accommodate greater blood flow. To achieve an erection, a man must experience vasodilation to allow more blood flow to the penis, and this is facilitated by cGMP. If the enzyme responsible for degrading cGMP is not inhibited, men with erectile dysfunction issues will have a more difficult time achieving or maintaining an erection, but Viagra can help overcome that by inhibiting the enzyme and permitting cGMP to work its vasodilation magic, which results in better blood flow and a greater chance of a man achieving or maintaining an erection.
Because of its effectiveness in facilitating vasodilation and improving blood flow, Viagra can also be used to treat altitude sickness and pulmonary arterial hypertension, both of which are responsive to less inhibited blood flow ensuring more oxygen gets to the lungs more efficiently. There are some trials that show that jet lag in hamsters has been alleviated by the administration of Viagra, and some athletes use it to enhance their performances, believing that the vasodilation action will improve their muscle function. The latter two uses of Viagra are not proven in human clinical trials and have not been listed as approved uses of the drug, however, Viagra has been shown to be effective in enhancing sexual function in women in whom antidepressants have caused difficulty in becoming or staying aroused or who have difficulty orgasming.
There are contraindications for using Viagra, including having had a recent stroke or heart attack or for men with cardiovascular health who should not be having sex, and there are side effects including flushing, stuffy nose, headache, sensitivity to light and blurred vision. However, Viagra has been on the market long enough and has been proven effective enough to consider it a viable treatment for sexual dysfunction for a range of people whose lives may be improved by taking it.
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I am self employed. General Practitioner in Melbourne, VIC. My special interest: male reproductive system.