Fluconazole is an antifungal drug, which means that it is employed as treatment of localized or systemic fungal infections, such as candidiasis, onychomycosis and other types of infections caused by fungi that are sensitive to this medication.
How does this medication works?
Fluconazole inhibits the growth and development of fungi, which is called in medical terms as a “fungistatic” effect. It does not directly kill the fungi, but it inhibits their growth to the point where they are usually eliminated and neutralized by the immune cells of the human body. The medication can be “fungicidal” for certain species, meaning that it can kill certain vulnerable fungi if the dosage is high enough.
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Example of fungi species sensitive to Fluconazole include Candida, Cryptococcus neoformans, Microsporum, Blastomyces dermatitidis and other types of fungi. If you suffer from a fungal infection, then a doctor specialized in treating infectious diseases can evaluate the signs and symptoms and decide whether the type of the fungi involved is sensitive to Fluconazole through a series of tests or physical examination.
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How does Fluconazole work to inhibit the growth of vulnerable fungi and stop fungal infections?
Fluconazole inhibits an enzyme called 14-alpha-demethylase, which is mainly found in the fungi. The enzyme is responsible for the production of an active component that is incorporated in the protective fungal membrane, which is called ergosterol. Without ergosterol, the fungi lose the capacity to form colonies, grow and multiplicate in sufficient numbers, which is how the fungistatic effect of Fluconazole is explained. Fluconazole has almost no influence on the similar enzymes found in the human body, and targets specifically the fungal metabolic system.
Treatment safety
Treatment with Fluconazole for fungal infections should be initiated only after a careful medical evaluation, because certain fungi species may become resistant to Fluconazole if the treatment is elaborated incorrectly or the dosage is too low. It is highly recommended to avoid starting treatment on your own, and consult a qualified physician who can evaluate your symptoms and determine whether Fluconazole is useful in your case. Individuals who are prescribed Fluconazole but have kidney problems should inform their doctor about this circumstance because dosage adjustments may be necessary. Fluconazole has been approved as a solid treatment of fungal infections, but, as with any other medication, it can cause side effects. These may include stomach pain, nausea, vomiting, headaches, diarrhea or skin rashes, but they are rare occurrences. You are encouraged to discuss with your physician any unpleasant side effects or symptoms that you may experience during Fluconazole treatment because dosage adjustments may be necessary to minimize the unpleasant effects. If you take other drugs, your doctor can evaluate how they may interfere with Fluconazole to ensure a safe treatment.
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