Cialis (Tadalafil) is a phosphodiesterase type 5 (PDE5) inhibitor drug that is usually prescribed in Australia for men who are experiencing difficulties with their erectile response to sexual arousal. Erectile dysfunction (ED) is a very common sexual disorder among men, and PDE5 inhibitors, such as Tadalafil, Sildenafil or Avanafil, are commonly indicated as solid treatment for ED symptoms. Erectile dysfunction is caused by a physiologic imbalance that occurs after sexual arousal is experienced by a man, followed by several psychological or chemical deficiencies that are related to the blood vessels in the cavernous bodies of the penis.
Cialis is the best Viagra alternative
All PDE5 inhibitors have approximately the same mechanism of action and effects, but the differences between them may consist in the absorption rates, duration of their effects and other subtle parameters. Cialis (Tadalafil 20mg) is unique in the sense that its action duration is much longer when compared to the other drugs from the same category. Unlike Sildenafil, for example, which is active for about 2-3 hours after administration, the beneficial effects of Tadalafil in restoring the adequate erection response are maintained for up to 36 hours or even more. This is why Cialis has also been called the “weekend pill”, which is due to its ability to sustain proper erectile responses for up to two days, provided the man is sexually aroused.
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What is the precise Cialis mechanism of action and how does it achieve its functions of sustaining a strong erection in men suffering from ED?
A nerve signal travels from the brain to the nerve endings in the blood vessels located in the penis every time a man is sexually aroused. The nerve endings in specialized blood vessel structures called the cavernous bodies release nitric oxide (NO). This “messenger” chemical activates an enzyme that is responsible for the release of cyclic GMP, the central chemical component of the erectile physiological cascade of events. Cyclic GMP directly stimulates the blood vessels in the cavernous structures of the penis, which results in a potent dilation of the blood vessels and the facilitation of blood entry. This is how an erection is achieved under normal physiologic conditions. There is a destructive enzyme, however, called PDE5, which has the role to terminate the effects of cGMP, and therefore is able to weaken the erectile response. PDE5 blockers are able to inhibit this enzyme, which leads to a solid accumulation of cyclic GMP in the blood vessels and their sustained dilation. Large amounts of available cyclic GMP after Cialis administration are causing an adequate erection every time the man is sexually stimulated.
Talk to your physician and inform him or her about your decision to take Cialis for your erectile problems to ensure a safe treatment and a diminished probability of side effects.
I am self employed. General Practitioner in Melbourne, VIC. My special interest: male reproductive system.